tetra hydro derivativesby restoration of delta4-double communication and 3-ketogruppy, then conjugates, basically with glucuronic acid. Of Testosteron-Depotum are formed 17-ketosteroidy androsterone and etiocholanolone which conjugates with Zinci sulfases and are excreted in such kind with urine. Estrogens (for example, Oestradiolum) turn to a theelol and Estronum, then conjugates with glucuronic acid and Zinci sulfases.
At chronic illnesses of a liver the metabolism of estrogens and Testosteron-Depotum is often broken that leads to occurrence of vascular asterisks, a hair fall on a pubis and in axillary area, an atrophy of testicles. At men with a cirrhosis (especially alcoholic) Testosteron-Depotum and an androstendion owing to portocaval shuntings are to a lesser degree metabolized in a liver and turn in peripheric tissues to Oestradiolum and Estronum; the gynecomastia as a result develops. Feminization at them can be caused and direct toxic influence of alcohol on the gipotalamo-gipofizarno-gonadal system, accompanied depression of serumal concentration of Testosteron-Depotum.
Similar disturbances arise at sick of a hemochromatosis as a result of iron adjournment in structures gipotalamogipofizarno-gonadnoj systems. However the gynecomastia at them often is not present - probably, in connection with simultaneous depression of serumal concentration of an androstendion - the basic precursor of estrogens.
Estrogens can immediately break secretory function of a liver. Oestradiolum and other estrogens (for example, a part of peroral contraceptives) influence allocation of cholic acids and aggravate disturbance of formation of direct bilirubin at patients with a syndrome the Cudgel-dzhonsona. They cause also rising of activity serumal ЩФ.
Some metabolites of sexual hormones (for example, etiocholanolone and a pregnandiol) stimulate amino levulinat synthase that conducts to augmentation of allocation of a porphobilinogen. Similar action is rendered onlyby the form of these hormones and consequently at an alcoholic cirrhosis activity aminolevulinatsynthase can increase.
The liver provides also some important vasoactive substances (for example, adrenaline and a bradikinin). Probably, rising of concentration of adrenaline at illnesses of a liver conducts to constantly raised warm emission that promotes development of an ascites and hepatorenal a syndrome.
